Blow-up of solutions for weakly coupled systems of complex Ginzburg-Landau equations

Blow-up phenomena ofvweakly coupled systems of several evolution equations, especially complex Ginzburg-Landau equationsvis shown by a straightforward ODE approach not so-called test-function method, which gives the natural blow-up rate. The difficulty of the proof is that, unlike the single case, terms which come from the fact that the Laplacian cannot be absorbed into the weakly coupled nonlinearities. A similar ODE approach is applied to heat systems by Mochizuki to obtain the lower estimate of lifespan.Comment: 17page

炭酸脱水酵素8(CAR8)は腸管内分泌細胞からの長鎖脂肪酸応答性GLP-1分泌を負に制御する

京都大学新制・論文博士博士(医学)乙第13429号論医博第2233号新制||医||1053(附属図書館)京都大学大学院医学研究科医学専攻(主査)教授 長船 健二, 教授 妹尾 浩, 教授 川口 義弥学位規則第4条第2項該当Doctor of Medical ScienceKyoto UniversityDFA

Splitting a coordination with with

By investigating data on Japanese particle to ‘with/and’, this paper provides a unified analysis of three types of construction containing the particle to. We argue that a single to particle coordinating two elements is a conjunction particle (single to construction), while to selecting the coordination phrase (multiple to construction) and to adjoined to a single element (split to construction) are comitative postpositions. Under the proposal, the split to construction and the multiple to construction share the same underlying structure containing the single to construction. We also show that Russian coordinative and discontinuous comitatives are derived in a similar way to Japanese, following Ionin and Matushansky (2003). Our proposal suggests that a discontinuous comitative phrase and its associate universally form a constituent in a base structure

Multidirectional Approach to the Semantics of Have:Seeking a Unified Way of Teaching Its Polysemy to the EFL Students

Have is one of the most polysemous words. This workshop will discuss the semantics of have through three presentations and a discussion forum. The presentations will focus (i) on have in the causative constructions, (ii) on the “habitat segregation” of idioms using have, and (iii) on some constructions denoting location including constructions with have. In the discussion forum, we will discuss on the semantics of have and present an effective way of teaching the word to the EFL students.Article2015 Arts, Humanities, Social Sciences & Education PROCEEDINGS.2015:(2016)conference pape

Bipedal Robot Running: Human-like Actuation Timing Using Fast and Slow Adaptations

We have been developing human-sized biped robots based on passive dynamic mechanisms. In human locomotion, the muscles activate at the same rate relative to the gait cycle during running. To achieve adaptive running for robots, such characteristics should be reproduced to yield the desired effect. In this study, we designed a central pattern generator (CPG) involving fast and slow adaptation to achieve human-like running using a simple spring-mass model and our developed bipedal robot, which is equipped with actuators that imitate the human musculoskeletal system. Our results demonstrate that fast and slow adaptations can reproduce human-like running with a constant rate of muscle firing relative to the gait cycle. Furthermore, the results suggest that the CPG contributes to the adjustment of the muscle activation timing in human running.Comment: 15 pages, 12 figures, submitted to Advanced Robotic

4-(2,5-Dimethyl-1H-pyrrol-1-yl)-N-(2,5-dioxopyrrolidin-1-yl) benzamide improves monoclonal antibody production in a Chinese hamster ovary cell culture

There is a continuous demand to improve monoclonal antibody production for medication supply and medical cost reduction. For over 20 years, recombinant Chinese hamster ovary cells have been used as a host in monoclonal antibody production due to robustness, high productivity and ability to produce proteins with ideal glycans. Chemical compounds, such as dimethyl sulfoxide, lithium chloride, and butyric acid, have been shown to improve monoclonal antibody production in mammalian cell cultures. In this study, we aimed to discover new chemical compounds that can improve cell-specific antibody production in recombinant Chinese hamster ovary cells. Out of the 23,227 chemicals screened in this study, 4-(2,5-dimethyl-1H-pyrrol-1-yl)-N-(2,5-dioxopyrrolidin-1-yl) benzamide was found to increase monoclonal antibody production. The compound suppressed cell growth and increased both cell-specific glucose uptake rate and the amount of intracellular adenosine triphosphate during monoclonal antibody production. In addition, the compound also suppressed the galactosylation on a monoclonal antibody, which is a critical quality attribute of therapeutic monoclonal antibodies. Therefore, the compound might also be used to control the level of the galactosylation for the N-linked glycans. Further, the structure-activity relationship study revealed that 2,5-dimethylpyrrole was the most effective partial structure of 4-(2,5-dimethyl-1H-pyrrol-1-yl)-N-(2,5-dioxopyrrolidin-1-yl) benzamide on monoclonal antibody production. Further structural optimization of 2,5-dimethylpyrrole derivatives could lead to improved production and quality control of monoclonal antibodies